You are currently on:

G.U.M International

To find a retailer, please select your country & language. You will be redirected to your country's site.

  • International
  • Belgium
  • Germany
  • Denmark
  • Spain
  • France
  • Italy
  • Netherlands
  • Norway
  • Poland
  • Sweden
Previous
Jul 4, 2016
Next
Woman fills a glass with mouthwash

Chlorhexidine, the gold standard in dentistry, mode of action

The active ingredient Chlorhexidine (CHX) is considered the gold standard mouth rinse against which other newer mouth rinses are compared [1]. It has well known antiplaque properties, and is effective against multiple microbes including bacteria and oral yeasts such as candidiasis.

Years of documented research have established that CHX is safe, stable and effective at preventing and controlling plaque formation, breaking up existing plaque and inhibiting the development of gingivitis [2].

 

Sunstar GUM - Chlorhexidine, the gold standard in dentistry, mode of action

 

Mechanism of Action

Its mechanism of action is interesting. Being a cationic (positively charged) molecule, CHX binds to the negatively charged anions of bacteria and tooth surfaces (pellicles), inhibiting the formation of dental plaque. Its antibacterial action is due to the disruption of the bacterial cell membrane by the CHX molecules, increasing the bacterial cell permeability and resulting in cell lysis (i.e. cell membrane break-down).

Chlorhexidine (CHX) can be either bacteriostatic or bactericidal depending on the dose. Its principle mechanism of action is the inhibition of bacterial metabolism (bacteriostatic effect), limiting the growth of bacteria by interfering with bacterial DNA replication and bacterial cellular metabolism. At higher doses it can also have a bactericidal effect, leading to the complete destruction of bacterial cells (bactericidal effect).

CHX has a broad antimicrobial spectrum and exerts its action on both gram + and gram – bacteria, yeasts, dermatophytes, molds and lipophilic viruses.

 

Sustained action keeps working after rinsing time

CHX’s effect is sustained beyond the 30 second rinsing time recommended. This is because cationic CHX binds to negatively charged sites on the bacterial surface wall through electrostatic forces, allowing CHX to be active in the oral cavity beyond the pure rinse time.

While many other antibacterial agents are relatively quickly eliminated (such as by spitting out or ingestion) or are inactivated after use, CHX exhibits a continuous antibacterial activity over a period of more than twelve hours. Due to this long “residence time” in the oral cavity, even bacteria that rapidly re-colonize the oral tissue and saliva are inhibited or killed by the continued presence of CHX

Accordingly, CHX continues to be a gold standard ingredient for mouthwashes addressed to patient care post dental intervention. CHX is indicated for the maintenance phase post root planning, periodontal surgery and other oral surgeries, including dental implants and intermaxillary (IMF) fixation.

The GUM PAROEX® range contains different concentrations of Chlorhexidine and offers professional plaque control for optimal gum health.

[2] Bharati et al “Chlorhexidine : the gold standard mouth wash” Review Article, J. Pharm. Sci. & Res, Feb 2016

We use cookies to ensure that we give you the best experience on our website. To achieve this, we remember and store information about how you use it. This is done using simple text files called cookies which sit on your computer. By closing this message or navigating to a different page within this website, you consent to our cookies on this device in accordance with our cookie policy unless you have disabled them.